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젬크로와 함께 개발한 GEM을 활용한 논문 리스트 (2025년 기준)
2025/10/24

젬크로와 함께 개발한 GEM을 활용한 논문 리스트 (2025년 기준)

- 각 분야에서 주목 받는 성과로서 논문을 발표하신 연구자들께 축하와 감사를 전합니다.
- 여러분들이 더 좋은 성과를 낼 수 있도록, 저희도 모델 하나하나마다 우리 연구처럼 함께 노력하고 있습니다.  



2025

  • Ei24 cKO: Ei24 deficiency in brown adipocytes induces severe hypothermia under cold stress independent of UCP1 activity.  
    Nature communications  16:10426 (2025)

  • Db/Db: Comparison of the characteristics of non-alcoholic fatty liver disease in C57BL/6J-Leprem1hwl/Korl and C57BLKS/J-Lepr/J mice. 
    Experimental Animals 74(4):440-451 (2025)

  • hiFcRn KI: Advanced human FcRn knock-in mice for pharmacokinetic profiling of therapeutic antibodies. 
    Scientific Reports 15:27186 (2025)

  • hPCSK9 Tg: MicroRNA-1912 regulates cholesterol homeostasis by targeting PCSK9. 
    Molecular Therapy Nucleic Acids 6(3):102589 (2025)

  • Lgals4 KO: Galectin-4 potentiates CD8+ T cell immunity by enhancing MHC-I expression on dendritic cells. 
    Molecular Therapy 33(8):3662 (2025)

  • N2G: Generation of NOD-SCID mice with near-complete deletions of Il2rg and Prkdc for human cancer and HSC engraftment. 
    Transgenic Research 34(1):35 (2025)

  • N2G: Overcoming MET targeted drug resistance in MET amplified lung cancer by aurora kinase B inhibition. 
    BBA Molecular Cell Research 1872(7) (2025)

  • N2G-F8: Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs. 
    Experimental and Molecular Medicine 57(1):184-192 (2025)

  • Ei24 Tg: EI24 binds to IGF1R, enhancing glucose homeostasis and fostering healthy aging in male mice. 
    Front Aging 6:1564730 (2025)

  • Prdx5 KO: Peroxiredoxin 5 acts as a negative regulator of the sodium-chloride cotransporter involved in alleviating angiotensin II-induced hypertension. 
    Antioxidants 14(1):100 (2025)

  • SAMM50 KI: The SAMM50 rs3761472 causes mitochondrial dysfunction and metabolic dysfunction associated steatotic liver disease. 
    bioRxiv (2025)

  • VIPR2-ERT2CreERT2 TG: Mechanism of shear stress induced ATP release in ventricular myocytes roles of pannexin and mitochondria. 
    AJP Cell Physiology 329(3):C699 (2025)


2024

  • Fam19a5 KO: Is FAM19A5 an adipokine Peripheral FAM19A5 in wild type FAM19A5 knockout and LacZ knock in mice.
    Molecular Cells 47(12):100125 (2024)

  • hiACE2 KI: A humanized ACE2 mouse model recapitulating age and sex dependent immunopathogenesis of COVID 19.
    Journal of Medical Virology 96(9):e29915 (2024)

  • LDLR KO: Low-density lipoprotein receptor deficiency increases susceptibility to diet-induced non-alcoholic fatty liver disease in mice.
    Yakhak Hoeji 68(6):495-501 (2024)

  • Ob/Ob: Impact of the oral administration of polystyrene microplastics on hepatic lipid glucose and amino acid metabolism in C57BL/6Korl and C57BL/6-Lepem1hwl/Korl mice.
    International Journal of Molecular Sciences 25(9):4964 (2024)

  • Ob/Ob: Elucidation of the effects of hexandione as a metabolite of n hexane on cognitive impairment in leptin knockout mice.
    Toxicological Research 40:389-408 (2024)

  • MOR23 KO: MOR23 deficiency exacerbates hepatic steatosis in mice.
    FASEB Journal 38(20):e70107 (2024)

  • N2G: Dysfunctional adipocytes promote tumor progression through YAP/TAZ dependent cancer associated adipocyte transformation.
    Nature Communications 15:4052 (2024)

  • Pibf1 KO: PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.
    Nature Communications 15:1487 (2024)


2023

  • C3 KO: Complement C3-deficiency-induced constipation in FVB/N-C3em1Hlee/Korl knockout mice was significantly relieved by uridine and Liriope platyphylla L. extracts.
    International Journal of Molecular Sciences 24(21):15757 (2023)

  • ITF2 cKO: Protein stabilization of ITF2 by NF kappaB prevents colitis associated cancer development.
    Nature Communications 14:2363 (2023)

  • Ob/Ob: Dipterocarpus tuberculatus as a promising anti obesity treatment in Lep knockout mice.
    Frontiers in Endocrinology
     14 (2023)

  • Rag2 KO: Comparison of immunophenotypes between Rag2 knockout mice derived from two different sources.
    Laboratory Animal Research 39:2 (2023)

  • Trp53 HT: Short term carcinogenicity study of N-methyl-N-nitrosourea in FVB Trp53 heterozygous mice.
    PLoS ONE 18(1):e0280214 (2023)


2022

  • Ob/Ob: Similarities and differences in constipation phenotypes between Lep knockout mice and high fat diet-induced obesity mice.
    PLoS ONE 17(12):e0276445 (2022)

  • Ob/Ob: Effect of decellularized extracellular matrix bioscaffolds derived from fibroblasts on skin wound healing and remodeling.
    Frontiers in Bioengineering and Biotechnology 10 (2022)

  • Pde6b Rd10 KI: Stage dependent changes of visual function and electrical response of the retina in the rd10 mouse model.
    Frontiers in Cellular Neuroscience 16:926096 (2022)

  • Wap enhancer KO: Mammary enriched trans-cription factors synergize to activate the Wap super enhancer for mammary gland development.
    International Journal of Molecular Sciences 23:11680 (2022)


2021

  • C1qa KO: C1qa deficiency in mice increases susceptibility to mouse hepatitis virus A59 infection.
    Journal of Veterinary Science 22(3):e36 (2021)

  • HDAC2 KI: S nitrosylation of histone deacetylase 2 by neuronal nitric oxide synthase as a mechanism of diastolic dysfunction.
    Circulation 143:1912-1925 (2021)

  • Psmb8,9 dKO: mTORC1 induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of Muller glia.
    eLife 10:e70079 (2021)

  • Trp53 KO: Sensitivity to tumor development by TALEN mediated Trp53 mutant genes.
    Laboratory Animal Research 37(1):32 (2021)


2020

  • Cell line-Derived Xenograft (CDX), Pierce1 cKO: Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer.
    Oncogene  39, 5876-5887 (2020)

  • NKX3.1 KO: Deletion of NKX3.1 via CRISPR Cas9 induces prostatic intraepithelial neoplasia in C57BL6 mice.
    Technology in Cancer Research and Treatment 19 (2020)

  • p19 KO: Differential manifestation of ocular phenotypes in TALEN mediated p19arf knockout FVB N and C57BL/6J mouse lines.
    Genes and Genomics 42(9):1023 (2020)

  • VIPR2-ERT2CreERT2 Tg: Tamoxifen-inducible cardiac-specific Cre transgenic mouse using VIPR2 intron.
    Laboratory Animal Research 15:36:31 (2020)


2019

  • Adora2b KI: Cardioprotective role of APIP in myocardial infarction through ADORA2B.
    Cell Death and Disease 10:511 (2019)

  • Alb-ERT2-Cre-ERT2 TG: In vivo albumin traps photosensitizer monomers from self assembled phthalocyanine nanovesicles.
    Journal of the American Chemical Society 141, 1366 (2019)

  • p16Ink4a KO: Sexually dimorphic leanness and hypermobility in p16Ink4a/CDKN2A-deficient mice coincides with phenotypic changes in the cerebellum.
    Scientific Reports 9:11167 (2019)

  • Ei24 Tg, ApcMin: Effect of EI24 expression on the tumorigenesis of ApcMin/+ colorectal cancer mouse model.
    Biochem Biophys Res Commun 514(4): 1087-1092 (2019)

  • Rag2 R229Q KI: The R229Q mutation of Rag2 does not characterize severe immunodeficiency in mice.
    Scientific Reports 9:4415 (2019)

  • Tonsl KI: Hypomorphic mutations in TONSL cause SPONASTRIME dysplasia.
    American Journal of Human Genetics 104(3):439-453 (2019)


2018

  • CD47 KO: CRISPR/Cas9-mediated knockout of CD47 causes hemolytic anemia with splenomegaly in C57BL/6 mice.
    Laboratory Animal Research 34(4):302 (2018)

  • p16 KO, p19 KO, p27 KO: Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing.
    Laboratory Animal Research 34(4), 264-269 (2018)

  • Plac8 KO: CRISPR/Cas9-mediated generation of a Plac8 knockout mouse model.
    Laboratory Animal Research 34(4):279-287 (2018)

  • Rag2 KO: CRISPR/Cas9 mediated knockout of Rag-2 causes systemic lymphopenia with hypoplastic lymphoid organs in FVB mice.
    Laboratory Animal Research 34(4):166-175 (2018)

  • Rag2 KO, Il2rg KO: Differences between immunodeficient mice generated by classical gene targeting and CRISPR/Cas9 mediated gene knockout.
    Transgenic Research 27:241-251 (2018)

  • Tff1 KO: Disruption of the Tff1 gene in mice using CRISPR/Cas9 promotes body weight reduction and gastric tumorigenesis.
    Laboratory Animal Research 34(4):257-263 (2018)


~2016

  • EML4-ALK TG: Establishment of a conditional transgenic mouse model recapitulating EML4-ALK positive human non small cell lung cancer.
    Journal of Thoracic Oncology 12(3):491 (2016)

  • Prkdc KO, Foxn1 KO: Highly efficient gene knockout in mice and zebrafish with RNA guided endonucleases. 
    Genome Research 24:125-131 (2014)

  • Pibf1 KO: Knockout mice created by TALEN mediated gene targeting. 
    Nature Biotechnology 31:23-24 (2013)

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