젬크로와 함께 개발한 GEM을 활용한 논문 리스트 (2025년 기준)

- 각 분야에서 주목 받는 성과로서 논문을 발표하신 연구자들께 축하와 감사를 전합니다.
- 여러분들이 더 좋은 성과를 낼 수 있도록, 저희도 모델 하나하나마다 우리 연구처럼 함께 노력하고 있습니다.  


2025

• Ei24 cKO: Ei24 deficiency in brown adipocytes induces severe hypothermia under cold stress independent of UCP1 activity.  
  Nature communications  16:10426 (2025)
  
  

• Db/Db: Comparison of the characteristics of non-alcoholic fatty liver disease in C57BL/6J-Lepr^em1hwl/Korl and C57BLKS/J-Lepr/J mice. 
  Experimental Animals 74(4):440-451 (2025)
  
  

• hiFcRn KI: Advanced human FcRn knock-in mice for pharmacokinetic profiling of therapeutic antibodies. 
  Scientific Reports 15:27186 (2025)
  
  

• hPCSK9 Tg: MicroRNA-1912 regulates cholesterol homeostasis by targeting PCSK9. 
  Molecular Therapy Nucleic Acids 6(3):102589 (2025)
  
  

• Lgals4 KO: Galectin-4 potentiates CD8+ T cell immunity by enhancing MHC-I expression on dendritic cells. 
  Molecular Therapy 33(8):3662 (2025)
  
  

• N2G: Generation of NOD-SCID mice with near-complete deletions of Il2rg and Prkdc for human cancer and HSC engraftment. 
  Transgenic Research 34(1):35 (2025)
  
  

• N2G: Overcoming MET targeted drug resistance in MET amplified lung cancer by aurora kinase B inhibition. 
  BBA Molecular Cell Research 1872(7) (2025)
  
  

• N2G-F8: Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs. 
  Experimental and Molecular Medicine 57(1):184-192 (2025)
  
  

• Ei24 Tg: EI24 binds to IGF1R, enhancing glucose homeostasis and fostering healthy aging in male mice. 
  Front Aging 6:1564730 (2025)
  
  

• Prdx5 KO: Peroxiredoxin 5 acts as a negative regulator of the sodium-chloride cotransporter involved in alleviating angiotensin II-induced hypertension. 
  Antioxidants 14(1):100 (2025)
  
  

• SAMM50 KI: The SAMM50 rs3761472 causes mitochondrial dysfunction and metabolic dysfunction associated steatotic liver disease. 
  bioRxiv (2025)
  
  

• VIPR2-ERT2CreERT2 TG: Mechanism of shear stress induced ATP release in ventricular myocytes roles of pannexin and mitochondria. 
  AJP Cell Physiology 329(3):C699 (2025)
  

2024

• Fam19a5 KO: Is FAM19A5 an adipokine Peripheral FAM19A5 in wild type FAM19A5 knockout and LacZ knock in mice.
  Molecular Cells 47(12):100125 (2024)
  
  

• hiACE2 KI: A humanized ACE2 mouse model recapitulating age and sex dependent immunopathogenesis of COVID 19.
  Journal of Medical Virology 96(9):e29915 (2024)
  
  

• LDLR KO: Low-density lipoprotein receptor deficiency increases susceptibility to diet-induced non-alcoholic fatty liver disease in mice.
  Yakhak Hoeji 68(6):495-501 (2024)
  
  

• Ob/Ob: Impact of the oral administration of polystyrene microplastics on hepatic lipid glucose and amino acid metabolism in C57BL/6Korl and C57BL/6-Lep^em1hwl/Korl mice.
  International Journal of Molecular Sciences 25(9):4964 (2024)
  
  

• Ob/Ob: Elucidation of the effects of hexandione as a metabolite of n hexane on cognitive impairment in leptin knockout mice.
  Toxicological Research 40:389-408 (2024)
  
  

• MOR23 KO: MOR23 deficiency exacerbates hepatic steatosis in mice.
  FASEB Journal 38(20):e70107 (2024)
  
  

• N2G: Dysfunctional adipocytes promote tumor progression through YAP/TAZ dependent cancer associated adipocyte transformation.
  Nature Communications 15:4052 (2024)
  
  

• Pibf1 KO: PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.
  Nature Communications 15:1487 (2024)
  

2023

• C3 KO: Complement C3-deficiency-induced constipation in FVB/N-C3^em1Hlee/Korl knockout mice was significantly relieved by uridine and Liriope platyphylla L. extracts.
  International Journal of Molecular Sciences 24(21):15757 (2023)
  
  

• ITF2 cKO: Protein stabilization of ITF2 by NF kappaB prevents colitis associated cancer development.
  Nature Communications 14:2363 (2023)
  
  

• Ob/Ob: Dipterocarpus tuberculatus as a promising anti obesity treatment in Lep knockout mice.
  Frontiers in Endocrinology 14 (2023)
  
  

• Rag2 KO: Comparison of immunophenotypes between Rag2 knockout mice derived from two different sources.
  Laboratory Animal Research 39:2 (2023)
  
  

• Trp53 HT: Short term carcinogenicity study of N-methyl-N-nitrosourea in FVB Trp53 heterozygous mice.
  PLoS ONE 18(1):e0280214 (2023)
  

2022

• Ob/Ob: Similarities and differences in constipation phenotypes between Lep knockout mice and high fat diet-induced obesity mice.
  PLoS ONE 17(12):e0276445 (2022)
  
  

• Ob/Ob: Effect of decellularized extracellular matrix bioscaffolds derived from fibroblasts on skin wound healing and remodeling.
  Frontiers in Bioengineering and Biotechnology 10 (2022)
  
  

• Pde6b Rd10 KI: Stage dependent changes of visual function and electrical response of the retina in the rd10 mouse model.
  Frontiers in Cellular Neuroscience 16:926096 (2022)
  
  

• Wap enhancer KO: Mammary enriched trans-cription factors synergize to activate the Wap super enhancer for mammary gland development.
  International Journal of Molecular Sciences 23:11680 (2022)
  

2021

• C1qa KO: C1qa deficiency in mice increases susceptibility to mouse hepatitis virus A59 infection.
  Journal of Veterinary Science 22(3):e36 (2021)
  
  

• HDAC2 KI: S nitrosylation of histone deacetylase 2 by neuronal nitric oxide synthase as a mechanism of diastolic dysfunction.
  Circulation 143:1912-1925 (2021)
  
  

• Psmb8,9 dKO: mTORC1 induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of Muller glia.
  eLife 10:e70079 (2021)
  
  

• Trp53 KO: Sensitivity to tumor development by TALEN mediated Trp53 mutant genes.
  Laboratory Animal Research 37(1):32 (2021)
  

2020

• Cell line-Derived Xenograft (CDX), Pierce1 cKO: Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer.
  Oncogene  39, 5876-5887 (2020)
  
  

• NKX3.1 KO: Deletion of NKX3.1 via CRISPR Cas9 induces prostatic intraepithelial neoplasia in C57BL6 mice.
  Technology in Cancer Research and Treatment 19 (2020)
  
  

• p19 KO: Differential manifestation of ocular phenotypes in TALEN mediated p19arf knockout FVB N and C57BL/6J mouse lines.
  Genes and Genomics 42(9):1023 (2020)
  
  

• VIPR2-ERT2CreERT2 Tg: Tamoxifen-inducible cardiac-specific Cre transgenic mouse using VIPR2 intron.
  Laboratory Animal Research 15:36:31 (2020)
  

2019

• Adora2b KI: Cardioprotective role of APIP in myocardial infarction through ADORA2B.
  Cell Death and Disease 10:511 (2019)
  
  

• Alb-ERT2-Cre-ERT2 TG: In vivo albumin traps photosensitizer monomers from self assembled phthalocyanine nanovesicles.
  Journal of the American Chemical Society 141, 1366 (2019)
  
  

• p16Ink4a KO: Sexually dimorphic leanness and hypermobility in p16Ink4a/CDKN2A-deficient mice coincides with phenotypic changes in the cerebellum.
  Scientific Reports 9:11167 (2019)
  
  

• Ei24 Tg, ApcMin: Effect of EI24 expression on the tumorigenesis of ApcMin/+ colorectal cancer mouse model.
  Biochem Biophys Res Commun 514(4): 1087-1092 (2019)
  
  

• Rag2 R229Q KI: The R229Q mutation of Rag2 does not characterize severe immunodeficiency in mice.
  Scientific Reports 9:4415 (2019)
  
  

• Tonsl KI: Hypomorphic mutations in TONSL cause SPONASTRIME dysplasia.
  American Journal of Human Genetics 104(3):439-453 (2019)
  

2018

• CD47 KO: CRISPR/Cas9-mediated knockout of CD47 causes hemolytic anemia with splenomegaly in C57BL/6 mice.
  Laboratory Animal Research 34(4):302 (2018)
  
  

• p16 KO, p19 KO, p27 KO: Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing.
  Laboratory Animal Research 34(4), 264-269 (2018)
  
  

• Plac8 KO: CRISPR/Cas9-mediated generation of a Plac8 knockout mouse model.
  Laboratory Animal Research 34(4):279-287 (2018)
  
  

• Rag2 KO: CRISPR/Cas9 mediated knockout of Rag-2 causes systemic lymphopenia with hypoplastic lymphoid organs in FVB mice.
  Laboratory Animal Research 34(4):166-175 (2018)
  
  

• Rag2 KO, Il2rg KO: Differences between immunodeficient mice generated by classical gene targeting and CRISPR/Cas9 mediated gene knockout.
  Transgenic Research 27:241-251 (2018)
  
  

• Tff1 KO: Disruption of the Tff1 gene in mice using CRISPR/Cas9 promotes body weight reduction and gastric tumorigenesis.
  Laboratory Animal Research 34(4):257-263 (2018)
  

~2016

• EML4-ALK TG: Establishment of a conditional transgenic mouse model recapitulating EML4-ALK positive human non small cell lung cancer.
  Journal of Thoracic Oncology 12(3):491 (2016)
  
  

• Prkdc KO, Foxn1 KO: Highly efficient gene knockout in mice and zebrafish with RNA guided endonucleases. 
  Genome Research 24:125-131 (2014)
  
  

• Pibf1 KO: Knockout mice created by TALEN mediated gene targeting. 
  Nature Biotechnology 31:23-24 (2013)