Advanced Genetically Engineered Mouse Services

Supporting successful drug discovery with precision disease model mice.

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Why Choose GEMCRO?

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Researcher-Centric Partner

We don't just supply mice; we collaborate. From production management to consulting, we offer the value you need as a fellow researcher.

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Top-Tier Expertise

With over 30 years of dedication and world-class CRISPR technology, we have developed over 200 custom models for global researchers.

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Global Supply Network

We supply our extensive catalog of disease models or newly customized GEMs internationally as frozen embryos or frozen sperm.

GEMCRO Laboratory

Our Services

Custom Model Generation

Bespoke development of new GEM models tailored to your specific requirements.
All custom models can be supplied internationally as frozen sperm or frozen embryos.

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cKO

Conditional Knockout

Target gene deletion in specific tissues or timeframes using the Cre-loxP system. Ideal for studying genes essential for embryonic development.

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KI

Knock In

Insert specific DNA sequences or mutations into the genome. Used for disease mutation modeling and reporter systems.

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KO

Knock Out

Complete removal of target genes to study their function. Efficiently produced using advanced CRISPR/Cas9 technology.

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Targeted TG

Targeted Transgenic

Precise knock-in of transgenes into safe harbor loci (e.g., Rosa26, H11) for stable and predictable expression, overcoming the limitations of random insertion.

Expertise meets Supply

Ready-to-Use Models

Established disease models rapidly available for international supply.
Provided as frozen embryos or sperm to institutions capable of performing Embryo Transfer (ET) and In Vitro Fertilization (IVF).

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N2G Mice

Immunodeficient

Highly immunodeficient mice lacking mature T, B, and NK cells. The premier model for human cell and tissue engraftment (CDX/PDX) and oncology research.

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hiFcRn Mice

Humanized

Humanized FcRn models essential for evaluating the pharmacokinetics (PK) and half-life of human IgG antibodies and Fc-fusion therapeutics in vivo.

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hiACE2 Mice

Humanized

Humanized ACE2 models expressing the human ACE2 receptor. A critical and proven platform for SARS-CoV-2 (COVID-19) infectious disease pathogenesis and therapeutic research.

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Disease Models

Frozen Resources

Extensive catalog of ready-to-use disease models. Available for rapid global distribution entirely frozen (embryos/sperm) to ensure genetic stability.

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Strategic Partnerships for CROs
& Commercialization

Looking to develop proprietary models for commercial use or require specialized support for your CRO pipeline? We offer exclusive collaborative development and out-licensing opportunities tailored to your enterprise needs.

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How It Works

A transparent, step-by-step pipeline from initial consultation to successful global delivery.

Custom Model Generation

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1. Consultation

In-depth discussion of research goals.
Email us to inquire →

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2. Design & Vector

Validation of sgRNA/Cas9 off-target effects and precise donor vector construction.

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3. Generation

Microinjection, embryo transfer, and rigorous founder genotyping via PCR/Sequencing.

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4. Global Transfer

Secure cryogenic freezing (embryos/sperm) and international shipping to your facility.

Uncompromising Quality Control

Ensuring the genetic integrity and health status of your vital research models.

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    Strict SPF Facility Management

    All operations are conducted inside state-of-the-art Specific Pathogen Free (SPF) barriers. Environmental parameters and microbiological monitoring are strictly enforced to international standards.

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    Rigorous Genotyping Validation

    Every generated model undergoes comprehensive genetic validation. We strictly ensure that only offspring confirmed via PCR and Sanger sequencing from the F1 generation onwards are authorized for release.

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    Cryopreservation Viability

    Frozen embryos and sperm utilized for global transfer are subject to strictly controlled freeze-thaw recovery tests, verifying high viability rates prior to shipment authorization.

Scientific Leadership

World-class expertise driving innovation and uncompromising quality in every GEM project.

Han-Woong Lee PhD

CEO & R&D Director
  • Distinguished Professor Emeritus, Yonsei Univ
  • Former President of Korean Association of Laboratory Animal Science (KALAS)
  • Former Professor of Seoul Natl Univ Coll of Med, Sungkyunkwan Univ Sch of Med, and Yonsei Univ
  • Ph.D., Postdoc, & Res Associate, Albert Einstein Coll of Med

Jae Hoon Lee PhD

COO & Operating Director
  • Postdoc & Research Professor, Yonsei Univ
  • Ph.D., Sungkyunkwan Univ School of Medicine
  • B.S., Sungkyunkwan Univ

Yonghwan Kim PhD

CSO
  • Professor, Sookmyung Women's Univ
  • Director, Natl Res Foundation Core Facility Support Center (Ministry of Education)
  • Postdoc, Rockefeller Univ
  • Ph.D., Univ. of Texas

Su Cheong Yeom DVM, PhD

Head of GEM Division
  • Professor, Seoul National Univ
  • Director, Natl Rodent Resources Res Ctr
  • Chair, Korea Genome Editing Res Initiative
  • B.S., D.V.M., Ph.D. & Postdoc., Seoul Natl Univ